Antihistamines in Eosinophilic Esophagitis

  • STATUS
    Not Recruiting
  • participants needed
    50
  • sponsor
    Mayo Clinic
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Updated on 16 February 2024
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antihistamines
eosinophil count
loratadine
esophagitis
famotidine
eosinophils

Summary

Researchers are assessing the safety and effectiveness of antihistamines in the treatment of eosinophilic esophagitis.

Description

The purpose of this research is to determine if antihistamines are safe and effective for the treatment of eosinophilic esophagitis. Antihistamines are frequently used for the treatment of gastroesophageal reflux disease and allergic disorders, and we hypothesize they will be effective in the treatment of eosinophilic esophagitis as well. The two antihistamines used in this study are loratadine and famotidine.

Details
Condition Eosinophilic esophagitis
Age 18years - 100years
Treatment Placebo, Famotidine, Loratadine
Clinical Study IdentifierNCT04248712
SponsorMayo Clinic
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

b'Patients over the age of 18, male and female.'
b'Patients who carry the diagnosis of EoE based on esophageal biopsies obtained within 6'
b'months prior to enrollment (>15 eosinophils per hpf on at least 2 esophageal levels)'
b'Subjects must be able to give appropriate informed consent'

Exclusion Criteria

b'Not willing or able to sign consent.'
b'Patients who have used topical or systemic corticosteroid therapy for any reason in'
b'the previous 6 weeks.'
b'Patients who have been treated with acid-suppressing medications (PPI or H2 receptor'
b'antagonists) in the previous 6 weeks.'
b'Patients on immunosuppressive or immunomodulating medications in the previous 6 weeks.'
b'Patients with known allergies or hypersensitivity to anti-histamines.'
b'Patients who have contraindications to the procurement of esophageal biopsies'
b'including patients who have known bleeding disorders, a history of bleeding diathesis,'
b'or who are currently using warfarin or clopidogrel.'
b'Patients who have a contraindication to the performance of an'
b'esophagogastroduodenoscopy (EGD) including previous cardiopulmonary arrest during an'
b'endoscopic procedure.'
b'Patients who are pregnant.'
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antihistamines
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