Co-transplantation of MSC in the Setting of Allo-HSCT

  • STATUS
    Recruiting
  • End date
    Dec 1, 2025
  • participants needed
    120
  • sponsor
    Fujian Medical University
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Updated on 16 February 2024
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ejection fraction
cell transplantation
graft versus host disease

Summary

Mesenchymal stem cells (MSCs) are known to exhibit immunomodulatory, anti-inflammatory, and pro-angiogenic properties, and therefore have the potential to improve the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) .The study is aimed to identify and evaluate the potential benefits of MSCs infusion during allogeneic HSCT, with regard to the engraftment, graft versus host disease (GVHD), post-transplant relapse and survival.

Details
Condition Allogeneic Hematopoietic Stem Cell Transplantation
Age 65years or below
Treatment Cotransplant with MSCs
Clinical Study IdentifierNCT04247945
SponsorFujian Medical University
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Signed written informed consent
Aged <65 years
Willing to transplant
Cardiac: Left ventricular ejection fraction 50%
Adequate renal and hepatic function
Performance status: Karnofsky 70%

Exclusion Criteria

Pregnant or lactating females
Any co-morbidity precluding the administration of MSCs
Clear my responses
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