Tissue K+ in Primary Hyperaldosteronism

  • STATUS
    Recruiting
  • participants needed
    10
  • sponsor
    University of Erlangen-Nürnberg Medical School
Send
Updated on 16 February 2024
See if I qualify
electrolytes
potassium
aldosterone
hyperaldosteronism
electrolyte

Summary

Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism. Besides, former animal studies applying chemical electrolyte analysis indicate that this aldosterone induced sodium storage might be accompanied by intracellular potassium loss. Wether such an intracellular tissue Potassium loss occurs in vivo in patients with hyperaldosteronism and if this deficiency can be corrected by treatment is unclear. The investigators will employ 39K-MR Imaging at 7Tesla to further assess this hypothesis.

Description

Patients diagnosed with primary hyperaldosteronism will be investigated using 23Na-MRI and 39K-MRI at 7 Tesla to assess tissue sodium and potassium content. Measurements will be conducted before treatment of hyperaldosteronism and three months after adrenal surgery or medical treatment (Spironolactone or Eplerenone). Furthermore, blood pressure, body water distribution (by bioimpedance spectroscopy), serum electrolytes as well as monocyte function will be assessed.

Details
Condition Hyperaldosteronism, Electrolyte Disturbance
Age 18years - 95years
Treatment Surgical Treatment of Hyperaldosteronism, Drug treatment of Hyperaldosteronism
Clinical Study IdentifierNCT04251780
SponsorUniversity of Erlangen-Nürnberg Medical School
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Primary Hyperaldosteronism diagnosed according to the endocrinological guidelines (J Clin Endocrinol Metab, May 2016)

Exclusion Criteria

Chronic kidney disease stage 3b and below (estimated GFR <30 ml/min according to CKD-EPI)
Acute kidney injury
Severe congestive heart failure (NYHA III and IV)
Liver Cirrhosis (Child B and C)
Pregnancy
Contraindications for MRI measurements: cardiac Pacemaker, claustrophobia, etc
Clear my responses
Read more

How to participate?

Step 1 Connect with a study center
Message sent successfully.
We have submitted the information you provided to the research team at the location you chose. For your records, we have sent a copy of the message to your email address.
If you would like to be informed of other studies that may be of interest to you, you may sign up for Patient Notification Service.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

First name*
Last name*
Email*
Phone number*
Other language

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Browse trials for

electrolytes
potassium
aldosterone
hyperaldosteronism
electrolyte

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.