Survival Significance of Molecular Pathology and Genetic Variation in Brain Gliomas

  • STATUS
    Recruiting
  • days left to enroll
    25
  • participants needed
    3000
  • sponsor
    The First Affiliated Hospital of Zhengzhou University
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Updated on 16 February 2024
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tumor resection
tumour resection
intracranial glioma
molecular pathology
glioma

Summary

This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology and genetic data. This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

Description

Precise classification based on molecular and genetic biomarkers/subgroups for gliomas is challenging. This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology (1p/19q co-deletion, MGMT methylation, IDH and TERTp mutations, etc) and genetic data (Whole exome sequencing, RNA sequencing, proteomics, etc). This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

Details
Condition Mutation, Glioma, Molecular Sequence Variation
Age 1years - 95years
Treatment Glioma groups based on molecular pathology or genetic variation
Clinical Study IdentifierNCT04216537
SponsorThe First Affiliated Hospital of Zhengzhou University
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients must have radiologically and histologically confirmed diagnosis of primary glioma
Life expectancy of greater than 3 months
Must receive tumor resection
Must have sufficient fresh frozen tissues for NGS
Signed informed consent

Exclusion Criteria

No gliomas
No sufficient amount of tumor tissues for detection of molecular pathology
Patients who are pregnant or breast feeding
Patients who are suffered from severe systematic malfunctions
Do not have sufficient fresh frozen tissues for NGS
Clear my responses
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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