Study of DC-CIK Combined With Chemotherapy for Advanced Solid Tumor

  • STATUS
    Recruiting
  • participants needed
    60
  • sponsor
    Yantai Yuhuangding Hospital
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Updated on 16 February 2024
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psychiatric disorder
cancer
platelet count
metastasis
solid tumor
brain metastases
advanced solid tumor
advanced malignant solid tumor

Summary

Combinations of Dendritic cell-activated cytokine-induced killer cell (DC-CIK) With chemotherapy treatment may enhance the immune response and stop cancer cells from growing.

Description

Patients in group A will receive 4 cycles of DC-CIK treatments within 8 months. Patients in group B will have no immunotherapy. Chemotherapy are available in both groups.The investigators want to evaluate the efficacy of combination of DC-CIK with chemotherapy in patients with treatment-refractory solid tumors.

Details
Condition Solid Tumor
Age 10years - 90years
Treatment DC-CIK combined with Chemotherapy, Chemotherapy
Clinical Study IdentifierNCT04214717
SponsorYantai Yuhuangding Hospital
Last Modified on16 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients with treatment-refractory advanced solid cancer can not accept operation
Age 18 to 75 years
Eastern Cooperative Oncology Group (ECOG) score 2 points
estimate survival > 3 months
Blood White Blood Cell(WBC) 4109/L, Hb 100g/L, Platelet Count (PLT) 80109/L; Alanine amino transferase (ALT) and aspartate amino transferase (AST) 2 times of normal upper value; Serum Cr 2 normal upper value
Without any other malignant disease
With more than one scalable lesions
Patients Voluntary attempt, and informed consent
Women of child-bearing potential must have a negative pregnancy test because of the potentially dangerous effects of the preparative chemotherapy on the fetus

Exclusion Criteria

Patients who do not conform to the inclusion criteria
Patients with uncontrolled infection; underlying disease that was severe or life-threatening (such as uncontrolled brain metastasis )
Patients who were pregnant or lactating
ECOG perform status 2;4
Other situations that the researchers considered unsuitable for this study (such as mental illness, drug abuse, etc.)
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