Mechanisms and Innovations in Cardiac Resynchronisation Therapy
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- STATUS
- Recruiting
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- participants needed
- 60
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- sponsor
- Imperial College London
Summary
The aim of this study is to compare the effectiveness of multiple modalities of cardiac resynchronisation therapy using high precision acute electrical and haemodynamic measurements.These modalities include biventricular pacing and conduction system pacing utilising His bundle and left bundle pacing. Conduction system pacing is a more physiological form of pacing. We hypothesise that this will produce more effective cardiac resynchronisation.
Description
This is a single centre acute electrical/haemodynamic and observational study of a subgroup of patients with heart failure. A total of 60 will be recruited. The acute study involves within patient comparison of biventricular and conduction system pacing using detailed electrical mapping and high precision haemodynamic measurement protocol.
Participants will have permanent conduction system pacing if;
- Baseline left bundle branch block and QRS > 140ms or QRS >150ms and any QRS morphology AND
- Conduction system pacing is successful at reducing QRS duration by 20ms or more with satisfactory pacing parameters.
Participants who receive permanent conduction system pacing will have follow up at 6 weeks, 3 months, 6 months and 12 months. Non-invasive markers including mechanical activation pattern (echocardiography and cardiac MRI) and electrical activation pattern (ultra-high frequency electrocardiography) will be used to identify the characteristics of patients who benefit from conduction system pacing.
Details
| Condition | Right bundle branch block, Heart failure, Heart failure, Heart disease, Heart disease, Left Ventricular Systolic Dysfunction, Non-Specific Intraventricular Conduction Defect |
|---|---|
| Age | 18years - 100years |
| Treatment | His-bundle pacing. |
| Clinical Study Identifier | NCT04221763 |
| Sponsor | Imperial College London |
| Last Modified on | 16 February 2024 |
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