Berberine Supplementation, Sprint Interval Training, and Immune Function Study

  • STATUS
    Recruiting
  • days left to enroll
    57
  • participants needed
    40
  • sponsor
    University of Northern Colorado
Send
Updated on 4 April 2026
See if I qualify
Accepts healthy volunteers

Summary

The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are:

  • Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality?
  • Does short-term berberine use or sprint training improve measures of anaerobic power generation?
  • Does short-term berberine use or sprint training improve circulating biomarkers of inflammation?
  • Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?

Details
Condition Berberine, Sprint Training, Wellbeing, Anaerobic Power, Inflammation Biomarkers, Monocyte Function
Age 18years - 45years
Clinical Study IdentifierNCT07480018
SponsorUniversity of Northern Colorado
Last Modified on4 April 2026

Eligibility

 Yes No Not Sure

Inclusion Criteria

Males and Females
Aged 18-45
DASS-21 subscale scores indicating "Mild" or greater category for Depression ≥ 10, Anxiety ≥ 7, and Stress ≥ 11

Exclusion Criteria

Regular berberine intake in the last 2 months
Performs SIT regularly in the last month
Pregnant or planning to become pregnant
Chronic use of anti-inflammatory medication or medications that affect liver metabolism
Prior history of chronic conditions such as Cardiovascular Disease, Diabetes, and Cancer
Severe and untreated anxiety or depression
Severe Peanut Allergies
Any contraindications to performing high intensity exercise
Clear my responses
Read more

How to participate?

Step 1 Connect with a study center
Message sent successfully.
We have submitted the information you provided to the research team at the location you chose. For your records, we have sent a copy of the message to your email address.
If you would like to be informed of other studies that may be of interest to you, you may sign up for Patient Notification Service.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

First name*
Last name*
Email*
Phone number*
Other language

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Browse trials for

Accepts healthy volunteers

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.