Magnetocardiography in the Accurate Identification of Severe Coronary Lesions and Myocardial Necrosis

  • STATUS
    Recruiting
  • participants needed
    430
  • sponsor
    Qilu Hospital of Shandong University
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Updated on 10 November 2025
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Summary

Magnetocardiography (MCG) is a promising noninvasive and accurate method for detecting myocardial ischemia. Although progress has been made in this area, there is a lack of studies using up-to-date examination instruments for the calibration of MCG analysis. This is a prospective single-center study aiming to build accurate analytical models of MCG to detect coronary lesions and myocardial necrosis. Coronary lesions are measured by coronary angiography (CAG) or coronary CTA, and are defined by both the stenosis degree and the computer-simulated fraction flow reserve. Myocardial necrosis is examined and quantified by cardiac MR. Healthy volunteers, chest pain patients who will receive CAG or CTA examination, and patients with acute myocardial infarction will be enrolled in this study.

Details
Condition Chest Pain, Acute Coronary Syndrome, Myocardial Infarction
Age 18years - 79years
Clinical Study IdentifierNCT05392712
SponsorQilu Hospital of Shandong University
Last Modified on10 November 2025

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age 18-79 years old
The attending doctor or above has diagnosed the patient as acute myocardial infarction (NSTEMI, STEMI), the condition of whom is relatively stable, and CMR examination is feasible after evaluation
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Exclusion Criteria

Patients with known structural heart disease such as cardiomyopathy and valvular disease
Patients with arrhythmias such as atrial fibrillation, supraventricular tachycardia, and atrioventricular block that have not returned to normal
History of other cardiovascular diseases such as pulmonary embolism and aortic dissection
Patients with connective tissue diseases (lupus erythematosus, rheumatoid arthritis, dermatomyositis, polyarteritis nodosa, etc.) combined with cardiac complications
Obvious abnormal thyroid function, severe anemia or other blood diseases and other diseases that obviously affect the circulating blood supply
Obese (BMI>30kg/cm2) or underweight (BMI<18kg/cm2)
Patients with malignant tumors
Professional athletes, pregnant or breastfeeding women, alcoholics
Acute diseases or critical illnesses in other systems, such as acute or severe respiratory diseases, abnormal liver function or renal function, etc
Patients with infectious diseases or infectious diseases
Those who are unable or fail to perform magnetocardiography due to claustrophobia, physical impairment, etc
Due to various reasons such as allergy to contrast agents, metal implants in vivo that are prohibited from performing 1.5T MRI (such as prostheses or steel plates implanted in orthopaedics, uterine contraceptive device) and other reasons, those who cannot or fail to cooperate with the corresponding research requirements
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