Effect of Sacubitril-Valsartan on Cardiac Structure and Function

  • STATUS
    Recruiting
  • End date
    Dec 4, 2026
  • participants needed
    45
  • sponsor
    Mayo Clinic
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Updated on 20 January 2026
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Summary

The purpose of this study is to compare changes in cardiac structure and function, biomarkers, and patient reported outcomes between adults with congenital heart disease (ACHD) randomized to angiotensin receptor-neprilysin inhibitor (ARNI) therapy vs placebo.

Details
Condition Congenital Heart Disease
Age 18years or above
Clinical Study IdentifierNCT06693674
SponsorMayo Clinic
Last Modified on20 January 2026

Eligibility

 Yes No Not Sure

Inclusion Criteria

Congenital Heart Disease Diagnosis
Age 18 or Older

Exclusion Criteria

Stage IV chronic kidney disease defined as creatinine clearance <30 ml/min
Hyperkalemia defined as serum potassium >5.2 mmol/l
Hypotension defined as systolic blood pressure <100 mmHg
History of angioedema related to previous ACE or ARB therapy
Patients diagnosed with diabetes using Aliskiren
Pregnancy
Drug Therapies
Amifostine
Droperidol
Dantrolene
CYP3A4 Inhibitors
Obinutuzumab
Aliskiren
Lithium
Sparsentan
ACE inhibitor
ARB
ARNI
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