Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73

  • STATUS
    Recruiting
  • End date
    Mar 1, 2026
  • participants needed
    30
  • sponsor
    First Affiliated Hospital of Fujian Medical University
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Updated on 8 August 2025
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Accepts healthy volunteers

Summary

As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. In this study, we observed the safety, biodistribution and radiation dosimetry of 68Ga-dPNE in human volunteers. Furthermover, we conducted a comparative analysis of 68Ga-dPNE and 18F-FDG imaging to assess both the radiation dosimetry and diagnostic efficacy of 68Ga-dPNE.

Description

The boom in radiopharmaceuticals continues to persist, including their driving effects in the field of immunotherapy. CD73 (ecto-5'-nucleotidase), a key purine metabolic enzyme, catalyzes the conversion of extracellular nucleotides to adenosine, promoting tumor immune evasion and unfavorable clinical outcomes. Notably, CD73 is highly expressed in 74.3% of breast cancer cases, with its prevalence exceeding 45% in liver, gastric, colorectal, and ovarian cancers. As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. The present study aimed to evaluate the biodistribution, pharmacokinetics, and dosimetry of 68Ga-dPNE, and performed a head-to-head comparison with 18F-FDG PET/CT scans in patients with various cancers.

Details
Condition Malignant Tumour
Age 18years - 90years
Clinical Study IdentifierNCT06995976
SponsorFirst Affiliated Hospital of Fujian Medical University
Last Modified on8 August 2025

Eligibility

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Inclusion Criteria

Signed informed consent and be able to follow up

Exclusion Criteria

Pregnant or lactational women; who suffered from severe hepatic and renal
insufficiency
Clear my responses
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