No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track

  • STATUS
    Recruiting
  • participants needed
    60
  • sponsor
    Kafrelsheikh University
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Updated on 17 May 2025
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Summary

This study aims to assess the no-reflow in patients with STEMI after intracoronary glycoprotein IIb/IIIa inhibitors after opening of track in thrombus.

Description

ST-segment-elevation myocardial infarction (STEMI) is most commonly caused by rupture or erosion of an atherosclerotic plaque, resulting in acute occlusion of the coronary artery, and the preferred reperfusion strategy is primary percutaneous coronary intervention (PCI).

The no-reflow phenomenon is one of the most common causes of adverse cardiovascular events in patients STEMI.

In recent years, mechanical or pharmacological treatment strategies including adjunctive administration of glycoprotein IIb/IIIa inhibitors (GPI) have been proposed in patients with STEMI.

Details
Condition No-Reflow, STEMI, Intracoronary, Tirofiban
Age 18years or above
Clinical Study IdentifierNCT06966674
SponsorKafrelsheikh University
Last Modified on17 May 2025

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age ≥ 18 years old
Both sexes
Patients with STEMI. ST-segment elevated myocardial infarction is defined as typical chest pain >30 minutes with ST-segment elevation of >1 mm in at least 2 consecutive leads on the electrocardiogram or new-onset left bundle brunch block

Exclusion Criteria

Treatment with thrombolytic drugs in the previous 24 hours
Known malignancy
Thrombocytopenia
End-stage liver disease
Cardiogenic shock
Renal failure with glomerular filtration<30 ml/min
Contraindication for the use of tirofiban
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