Compare the Impact of Hemofilters and Hemodialyzers on Cytokine Removal During Cardiopulmonary Bypass in Pediatric Cardiac Surgery

  • STATUS
    Recruiting
  • End date
    Dec 1, 2025
  • participants needed
    40
  • sponsor
    Alnas Hospital
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Updated on 4 February 2025
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Summary

Cardiopulmonary bypass (CPB) allowed the correction of several congenital heart diseases such as intracardiac malformations, but it is well known that this is not a harmless procedure because it can lead to a systemic inflammatory response syndrome (SIRS), with activation of complement, cytokines, coagulation, and fibrinolysis pathways.

Due to economic causes, hemofilters became less available in low-resource countries, which forced perfusionists to use hemodialyzers instead during CPB. Preliminary data showed the potential safety of using hemodialyzers instead of hemofilters in Zero-balanced ultrafiltration.

The Objectives of the study This study aims to compare impact of hemofilters and hemodialyzers on cytokine removal during cardiopulmonary bypass in pediatric cardiac surgery.

Details
Condition Cardio-pulmonary Bypass, Cytokine
Age 15years or below
Clinical Study IdentifierNCT06792565
SponsorAlnas Hospital
Last Modified on4 February 2025

Eligibility

 Yes No Not Sure

Inclusion Criteria

Pediatric patients who are undergoing elective cardiothoracic surgery which cardiopulmonary bypass will be conducted
Age of patients from 1 year to 15 years
CPB duration more than 60 minutes

Exclusion Criteria

Pediatric patients with known signs of sepsis
Pediatric patients having had previous cardiothoracic surgery
Preoperative renal failure
Preoperative cardiogenic shock requiring the use of inotropes
Preoperative lactate concentration > 2 mmol/L
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