Association Between Venous Excess Ultrasound Grading System and Acute Kidney Injury in the ICU Population (VExUS ICU)

  • STATUS
    Recruiting
  • participants needed
    136
  • sponsor
    Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
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Updated on 18 September 2024
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Summary

Fluid resuscitation is one of the cornerstones of treatment in ICU patients. Nonetheless, excessive fluid administration can lead to fluid overload which has been associated with worse outcomes in the ICU. To prevent this, assessments of fluid responsiveness are commonly employed. However, fluid responsiveness does not take fluid tolerance into account. Fluid tolerance is the idea that a patient might still be fluid responsive but might already be at risk of the detrimental effects of fluid therapy. Recent developments in point of care ultrasound e.g. the Venous excess ultrasound might help identify patients at risk of fluid overload. However its association with patient relevant outcomes in the ICU remains unclear.

Description

This study will investigate the association between the venous excess ultrasound grading system (VExUS) and patient relevant outcomes such as acute kidney injury, mortality and length of stay.

A secondary analysis is planned where the association between VExUS and the lung ultrasound score will be investigated

Details
Condition Fluid Overload, Kidney Injury, Make-30
Age 18years or above
Clinical Study IdentifierNCT06585722
SponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Last Modified on18 September 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

all patients admitted to the ICU 18 years or older expected to stay in the ICU for more than 24 hours

Exclusion Criteria

any obstruction between the righ atrium and structures assessed by VExUS
a medical history of: Major cardiac shunts (e.g. atrial septum defect), Tricuspid regurgitation, dialysis, portal hypertension, pulmonary hypertension, interstitial lung disease, recipients of a kidney of liver transplant
patients in whom an ultrasound assesment is unfeasible e.g. a BMI over 40
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