OUD (Opioid Use Disorder) Target Trial
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- STATUS
- Not Recruiting
-
- End date
- Oct 31, 2026
-
- participants needed
- 80
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- sponsor
- Duke University
Updated on 9 September 2024
Summary
In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids.
The investigators are trying to learn two things:
- Can an MRI brain marker be used to predict which participants will be successful in quitting opioids with buprenorphine?
- Does adjunctive treatment with repetitive Transcranial Magnetic Stimulation (rTMS) help people quit using opioids more than a sham (placebo) version of rTMS?
In order to complete the study the investigators will ask participants to:
- Complete an MRI within 5-days of starting buprenorphine and again after they are on a full stable dose 1-3 weeks later.
- Undergo study-treatment with 50-sessions of either real or placebo rTMS in as little as 1-week (10-sessions-per-day for five days) or as long as over 6-weeks.
- Meet with the investigators once per week over the following 12-weeks to see if the participants have been able to quit using opioids over that time.
Details
| Condition | Opioid Use Disorder |
|---|---|
| Age | 18years or above |
| Treatment | sham repetitive transcranial magnetic stimulation (rTMS), Active repetitive transcranial magnetic stimulation (rTMS) |
| Clinical Study Identifier | NCT06585709 |
| Sponsor | Duke University |
| Last Modified on | 9 September 2024 |
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