Transcranial Direct Current Stimulation for Cognitive Improvement in Parkinson's Patients (tDCS) (tDCS)

  • STATUS
    Recruiting
  • End date
    Aug 31, 2025
  • participants needed
    40
  • sponsor
    Sanford Health
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Updated on 22 July 2024
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Summary

The investigators hypothesize that multi-session anodal tDCS (atDCS) of the left dorsolateral prefrontal cortex (LDLPFC) will induce long-lasting effects in improving cognitive function and reducing cognitive fatigue and fatigability in PD patients.

Description

Parkinson's disease (PD) is the second most common neurodegenerative disease (after Alzheimer's disease) and affects approximately one million people in the United States. Mild Cognitive Impairment (MCI) is very common even in early stages of PD. In addition to cognitive impairment, patients with PD also suffer cognitive fatigue (defined as the general sensation of difficulty in initiating cognitive activity) and cognitive fatigability (defined as "deterioration in the performance of attention tasks over an extended period of time"). Cognitive impairment, cognitive fatigue, and cognitive fatigability affect quality of life in patient with Parkinson's disease.

Transcranial direct current stimulation (tDCS) is a noninvasive and safe brain stimulation technique that has been shown to be effective in improving cognitive function in subjects with Parkinson's disease. During tDCS, low-voltage, low amplitude current is passed through a pair of surface electrodes placed over the areas of brain of interest.

The specific aim of this study is to examine if atDCS to LDLPFC at 2 milliamps (mA) for 20 minutes daily for 5 days will improve cognitive function and reduce cognitive fatigue and fatigability in PD patients with MCI. The study will examine if the effects may last for two weeks.

Details
Condition Parkinson Disease
Treatment Transcranial direct current stimulation, Sham (for transcranial direct current stimulation)
Clinical Study IdentifierNCT03191916
SponsorSanford Health
Last Modified on22 July 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of PD with at least two of the four diagnostic criteria for PD (tremor, rigidity, bradykinesia, and postural instability)
Meets criteria for MCI (21 ≤ MOCA scores ≤ 26)
Must be able to consent

Exclusion Criteria

Patients with dementia (MOCA < 21)
PD treatment using deep brain stimulation (DBS)
Diagnosis of psychosis
Diagnosis of multiple sclerosis
Diagnosis of stroke
Diagnosis of epilepsy
Diagnosis of chronic obstructive pulmonary disease
Diagnosis of congestive heart failure
Diagnosis of renal failure
Participants not fluent in English
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