COMPuter-assisted Self-training to Improve EXecutive Function (COMPEX)

  • STATUS
    Recruiting
  • participants needed
    700
  • sponsor
    Bispebjerg Hospital
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Updated on 22 July 2024
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Summary

This project explores the effects of specialized computer-based cognitive rehabilitation (CBCR) targeting executive functions in three groups of patients: Stroke, Cardiac Arrest and Parkinson's Disease. The effect of specialized CBCR is compared generally cognitively stimulating activities on a computer

Description

This project explores the effects of specialized computer-based cognitive rehabilitation (CBCR) targeting executive functions in three groups of patients: Stroke, Cardiac Arrest and Parkinson's Disease. The effect of specialized CBCR is compared to completing generally cognitively stimulating activities on a computer. A total of 600 patients (400 with stroke, 100 after heart attack and 100 with Parkinson's disease) is expected to be enrolled. All patients will complete a neuropsychological test battery assessing executive functions at inclusion, directly after the eight-week training period and at follow-up three months after the end of the intervention period. Furthermore, all patients will answer questionnaires concerning quality of life and ADL-measures at baseline, after the intervention and at follow-up. All patients will train for a period of 8 weeks, 5 times a week for 60 minutes regardless of their group allocation.

Details
Condition Parkinson Disease, Stroke, Cardiac Arrest, Cognitive Dysfunction, Executive Dysfunction
Age 18years - 100years
Treatment Computer-based cognitive rehabilitation (CBCR), General computer-based cognitive stimulation
Clinical Study IdentifierNCT04229056
SponsorBispebjerg Hospital
Last Modified on22 July 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

A diagnose of stroke, cardiac arrest or Parkinson's disease
Aged 18 years or older
Impaired working memory measured with CABPad working memory test, cut off for inclusion: 5 symbols or less backwards
Computer and internet access at home
Providing informed consent
Inclusion criteria specific for stroke
Inclusion within 6 months post-stroke
Stroke confirmed by clinical findings and imaging, both AIS and ICH is allowed
Initial stroke severity >/= NIHSS 3
Inclusion criteria specific for cardiac arrest
• Inclusion within 6 months post ictus
Inclusion criteria specific for Parkinson's disease
Clinical diagnosis of PD
Anti-parkinsonian medical treatment (dopaminergic or other)

Exclusion Criteria

Informed consent not provided
Other neurological or psychiatric disease which is expected to influence the patient's ability to participate in the trial according to the investigator
Not able to participate according to investigator
Exclusion criteria specific for stroke
Patients with massive anosognosia for executive dysfunction or patients with no subjective feeling of executive dysfunction (Patient sustains total denial of executive symptoms over time)
Patients with severe aphasia, in which it is unclear whether the patient's performance on a neuropsychological test-battery is due to aphasia and not executive dysfunction
Exclusion criteria specific for cardiac arrest • None
Exclusion criteria specific for PD
• Diagnosis of PD Dementia according to the MDS PD Dementia criteria
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