Cardiopulmonary Fitness in Children With Cystic Fibrosis Compared to Healthy Children (VOmuco)

  • STATUS
    Not Recruiting
  • participants needed
    345
  • sponsor
    University Hospital, Montpellier
Send
Updated on 6 February 2024
See if I qualify

Summary

Cystic fibrosis is the most common severe genetic disease with autosomal recessive transmission in the Caucasian population.

Its prognosis has improved considerably since the creation of Cystic Fibrosis centers (CF centers) and the improvement of symptomatic management (nutrition, antibiotic therapy, transplantation, etc.). Thus, the median survival rate is now 46 years, whereas it was 5 years in 1963.

The current challenges for cystic fibrosis patients are therefore twofold:

to continue to improve their survival, and to improve their quality of life (QoL) to promote "healthy ageing" with this pathology that begins in childhood.

In 1980, the WHO stated that functional capacity explorations best reflected the impact of chronic disease on health-related quality of life. Impairment of physical activity is common to chronic diseases, as in cystic fibrosis, where respiratory impairment and denutrition have been shown to contribute to reduced exercise tolerance and increased dyspnoea.

Measurement of the maximum oxygen consumption (VO2max) by a cardiopulmonary exercise test (CPET) is regarded as the gold standard exercise test in the measurement of aerobic exercise capacity.

In 2005 Pianosi et al. found that for children with cystic fibrosis, the rate of decline of VO2max measured by CPET was predictive of poorer quality of life.

Continuing to study the determinants associated with impaired aerobic fitness in cystic fibrosis offers the hope of considering appropriate therapies to further improve the quality of life of these patients.

In recent years, the arrival and widespread use of CFTR protein modulators in children has been a real turning point and makes it possible to envisage a drastic change in the history of this disease and its prognosis in the long term.

Thus, in this study, the investigators aimed to assess the aerobic fitness, assessed by a CPET, of children with cystic fibrosis, and to compare the results with healthy controls. Secondly, investigators wanted to identify the predictive factors of VO2max in children with cystic fibrosis.

Description

This retrospective study was carried out from November 2010 to September 2015 for control children (already published PMID: 29170358) : and July 2018 to December 2019 for cystic fibrosis children.

CPET were performed in the paediatric CPET laboratory of Montpellier University Hospital, France.

Children aged 7 to 17 years old were recruited. Two groups were identified: children with cystic fibrosis and healthy control children.

  1. The cystic fibrosis group consisted of children followed up every three months in the cystic fibrosis center of Montpellier University and referred to our paediatrician CPET laboratory in 2019 in the framework of an annual check-up. For the few patients who did not have a CPET in 2019, investigators included those who passed a CPET between July and December 2018. From patients' interviews, the absence of any physical activity, apart from physical education at school, was indicative of sedentary lifestyle.

Investigators also collected anthropometric data, radiological findings, CF-related markers of disease severity including CFTR genotype, microbiological infection, pancreatic insufficiency, cystic fibrosis-related diabetes (CFRD), and treatment including modulator data.

2. As in our previous similar CPET controlled paediatric studies, the control group consisted of children referred for non-severe functional symptoms linked to exercise (murmur, palpitation or dyspnoea) or for medical sports certificate. These children were classified as controls after a completely normal check-up, including physical examination, ECG, echocardiography and spirometry. Children with any chronic disease, medical condition (cardiac, neurologic, respiratory, muscular or renal), or medical treatment, and those requiring any further specialised medical consultation were not eligible.

CPET procedures were harmonized before the study started. Spirometry was systematically performed before the exercise test with a flow volume curve and measurement of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio (FEV1/FVC), with normalization to GLI 2012 Z scores. The same investigator coordinator manually calculated the VO2max and the ventilatory anaerobic threshold (VAT) using the V-Slope method. VO2max and VAT values were normalized in a percentage of the predicted VO2max using normal values from Wasserman and Cooper. The investigators considered VO2max below 80% of predicted value as pathologic value and a VAT value below 55 % of predicted VO2max was in favor of muscular deconditioning. All informations from CPET were recorded : heart rate (HR), blood pressure (BP), estimated VO2/HR, VAT, breathing reserves (BR), respiratory rate (RR), VE/VCO2 slope, Tidal Volume (VT).

Details
Condition Cystic Fibrosis in Children
Age 7years - 17years
Treatment VO2 max assessment
Clinical Study IdentifierNCT06242951
SponsorUniversity Hospital, Montpellier
Last Modified on6 February 2024

Similar trials to consider

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.