Impact of Pomegranate Seed Oil on Postprandial Cardiovascular Disease Risk Markers

  • STATUS
    Recruiting
  • participants needed
    15
  • sponsor
    University of Reading
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Updated on 22 September 2023
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Summary

Dietary fat plays a crucial role as a modifiable risk factor influencing both non-fasting lipaemia and vascular reactivity. Notably, the intake of dietary saturated fatty acids (SFAs) has been associated with adverse effects on blood lipid profiles, whereas increased consumption of unsaturated fatty acids (UFAs) has shown potential to improve lipid health. Pomegranate seed oil (PSO) stands out due to its high content of conjugated α-linolenic acids (CLnAs). However, research comparing the impact of these fatty acids on postprandial vascular function, particularly in postmenopausal women, remains limited. A cross-over, single-blind, randomised acute postprandial study will be conducted in 15 healthy postmenopausal women. Participants will be assigned to consume the test meals either a placebo (50 g of mixed fat; 4:0.5:0.5 palm oil: rapeseed oil: safflower oil) or PSO (40 g of mixed fat and 10g of PSO) in random order on 2 separate occasions, with 4-6 weeks between each study visit. The anthropometric, blood pressure, and arterial stiffness, will be taken for each study visit. Blood samples will be collected for the measurement of fasting lipids, glucose, insulin, inflammatory markers, and whole blood culture. The findings from this study will contribute to the evidence base on how consuming meals rich in PSO influence the level of blood lipids as well as other biomarkers for cardiovascular disease.

Details
Condition Postmenopausal Women
Age 65years or below
Treatment Pomegranate seed oil, Mixed vegetable oil
Clinical Study IdentifierNCT06042673
SponsorUniversity of Reading
Last Modified on22 September 2023

Eligibility

 Yes No Not Sure

Inclusion Criteria

Postmenopausal women who have been postmenopausal for at least 12 months
Aged 65 and under years
Serum TAG < 2.3 mmol/l
Body mass index (BMI) between 18-35 kg/m2
Fasting total cholesterol < 7.5 mmol/l
Fasting glucose concentration <7 mmol/L

Exclusion Criteria

Smokers
Medical history of myocardial infarction or stroke in the past 12 months
Diabetes (defined as fasting glucose > 7.0 mmol/l) or other endocrine disorders
Kidney, liver, pancreas or gastrointestinal disorder
Hypertension (blood pressure > 140/90 mmHg), cancer, medication for hyperlipidaemia (e.g. statins), hypertension or, inflammation
Anaemia (<115 g/L haemoglobin)
Taking any dietary supplements known to influence lipids/gut microbiota (e.g. plant stanols, fish oil, phytochemicals, natural laxatives, probiotics and prebiotics)
Drinking in excess of 14 units of alcohol per week
Planning on a weight-reducing regime
Parallel participation in another dietary intervention study
Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study
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