PET MRI as a Staging Tool for Head and Neck Cancer

  • STATUS
    Recruiting
  • participants needed
    20
  • sponsor
    Hoag Memorial Hospital Presbyterian
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Updated on 29 November 2021
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Summary

To explore the use of PET/MRI in the staging and pretreatment evaluation of patients with head and neck cancer and to compare this modality to standard PET/CT imaging.

Description

This study is a prospective clinical study whereby an emerging technology, PET/MRI will be compared to a more standard imaging modality, PET/CT, using newly diagnosed head and neck cancer patients as subjects. PET/MRI will also be used in this study to explore the merits of this new technology in determining extent of disease, functional impact, and potential treatment outcome.
In this study, subjects suitable for enrollment will be identified by the investigators involved in the study. These subjects will be identified through contact with these investigators and referred for enrollment per protocol. This protocol will include determining enrollment suitability based on inclusion and exclusion criteria. Once accepted as a candidate for the study, the newly diagnosed head and neck cancer patients will undergo both PET/CT and PET/MRI imaging within one week of each other. These studies will then be reviewed by a radiologist specializing in Head and Neck radiology familiar with PET imaging. The studies will be compared for any imaging differences. The imaging findings will then be correlated with pathological findings after surgery to determine if there are any consistent findings that correlate with adverse pathological findings, if found.
The specific imaging data points to be determined by a radiologist will be tumor and metastatic disease size, SUV uptake, specific anatomic structures involved with tumor, imaging irregularities and characteristics of those imaging irregularities of the involved structures locally and regionally (if present), imaging characteristics of the different phases of MRI (T1, T2, etc.), and any other notable imaging characteristic.

Details
Condition Head Cancer, Neck Cancer
Age 18years or above
Clinical Study IdentifierNCT04750434
SponsorHoag Memorial Hospital Presbyterian
Last Modified on29 November 2021

Eligibility

 Yes No Not Sure

Inclusion Criteria

Active head and neck cancer that require PET/CT regardless of the point of treatment
TNM staging I or II

Exclusion Criteria

Patients whose primary treatment option is chemotherapy or radiation therapy (not surgical)
Implanted pacemakers
Intracranial aneurysm clips
Cochlear implants
Certain prosthetic devices
Implanted drug infusion pumps
Neurostimulators
Bone-growth stimulators
Certain intrauterine contraceptive devices; or
Any other type of iron-based metal implants
MRI should not also be used on persons with the presence of internal metallic objects such as bullets or shrapnel, as well as surgical clips, pins, plates, screws, metal sutures, or wire mesh
Subject with breast tissue expanders
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