Immune Score Based Radiomics in Nasopharyngeal Carcinoma

  • STATUS
    Recruiting
  • End date
    Dec 19, 2027
  • participants needed
    494
  • sponsor
    Zhejiang Cancer Hospital
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Updated on 19 November 2021
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Summary

In nasopharyngeal carcinoma (NPC), tumor, node and metastasis (TNM) staging system is the main tool for determining treatment strategy and assessment of prognosis. However, the prognoses of patients with the same TNM stage after similar treatment vary widely. The aim of this study is to establish an immune score based radiomic staging system for NPC.

Description


Details
Condition Nasopharyngeal Carcinoma
Age 18years - 70years
Treatment Immune Score Based Radiomics
Clinical Study IdentifierNCT05126160
SponsorZhejiang Cancer Hospital
Last Modified on19 November 2021

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patients with newly histologically confirmed non-keratinizing/keratinizing
carcinoma
ECOG Performance status: 0-1 With normal liver function test (ALT, AST
≤2.5ULN) Renal: creatinine clearance ≥60ml/min Without hematopathy,marrow: WBC
>4109/L, HGB>90G/L, and PLT>100109/L. Written informed consent Exclusion
Criteria: Contraindications for MRI scan Prior malignancy (except adequately
treated carcinoma in-situ of the cervix or · basal/squamous cell carcinoma of
the skin) Previous chemotherapy or radiotherapy (except non-melanomatous skin
cancers outside the intended RT treatment volume) Patient is pregnant or
lactating Any severe intercurrent disease, which may bring unacceptable risk
or affect the compliance of the trial, for example, unstable cardiac disease
requiring treatment, renal disease, chronic hepatitis, diabetes with poor
control (fasting plasma glucose >1.5×ULN), or emotional disturbance
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