Dyspnea in Stable Patients With Coronary Artery Disease.

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    National Research Center for Preventive Medicine
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Updated on 5 August 2020
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stenosis
coronary artery disease
dyspnea
exercise test
angiography
ischemia
myocardial infarction
infarct
angina pectoris
arterial disease
coronary artery stenosis
exercise stress test
typical angina

Summary

Single-centre prospective study to characterize causes of dyspnea in stable patients with coronary artery disease and evaluate the possibility to determine the cause of dyspnea before in-depth examination.

Description

Stable patients with dyspnea and coronary artery disease will be included in this single-centre prospective study. In addition to routine clinical examination patients will be interviewed to determine the nature of shortness of breath, angina, presence of chronic heart failure or anxiety using the Medical Research Council Dyspnea scale, the visual analog scale of dyspnea, Borg scale, modified "dictionary" of dyspnea, G. Rose questionnaire, Seattle Angina Questionnaire, Framingham criteria for chronic heart failure and the SHOCK scale. During the subsequent in-depth examination including thyroid hormones, NT-proBNP, hsTroponin, ECG monitoring, six-minute walk test, stress-echo with a diastolic stress test, spirometry and coronary angiography (if necessary) main reason for dyspnea will be established. Possibilities of early (before in-depth examination) determination the reason for dyspnea in stable patients with coronary artery disease will be evaluated.

Details
Condition Coronary Artery Disease, Coronary Artery Disease, Coronary heart disease, Dyspnea
Age 100years or below
Treatment Scales for assessment of symptoms
Clinical Study IdentifierNCT04408612
SponsorNational Research Center for Preventive Medicine
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

Stable patients with shortness of breath and established diagnosis of coronary artery disease (at least 1 of the following signs)
history of myocardial infarction
typical angina without suspected other cause of pain
myocardial ischemia documented by ECG changes during symptoms and/or by results of the stress test
coronary artery stenosis >50% according to coronary angiography
Signed informed consent

Exclusion Criteria

Acute coronary syndrome (myocardial infarction, unstable angina) in the previous month
Hospitalization with decompensation of CHF in the previous 6 months (including CHF decompensation as the main reason for current hospitalization)
Diseases with an unfavourable prognosis (terminal CKD, CHF NYHA IV, a lung disease with severe respiratory failure)
Contraindications to bicycle stress echocardiography
Atrial Fibrillation at the time of hospitalization, when the decision not to restore the sinus rhythm
Mental illnesses and disorders, dementia, drug or alcohol dependence
Known oncological diseases
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stenosis
coronary artery disease
dyspnea
exercise test
angiography
ischemia
myocardial infarction
infarct
angina pectoris
arterial disease
coronary artery stenosis
exercise stress test
typical angina

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