Evaluation of a TDM Program for Intensive Care Patients in the Cerebrospinal Fluid

  • STATUS
    Recruiting
  • participants needed
    60
  • sponsor
    Ludwig-Maximilians - University of Munich
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Updated on 5 August 2020
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Summary

Therapeutic drug monitoring of antibiotics in critically ill patients is a present research topic of the last ten years. Research results have shown subtherapeutic blood concentrations in those patients. However, the amount of antibiotics in the cerebrospinal fluid (CSF) in patients with ventriculitis or meningitis is still unclear. This study is a prospective study to evaluate the concentration of different antibiotics in the CSF in patients with an external ventricular drainage compared to antibiotic blood concentration.

Description

Bacterial infections are still associated with a high mortality in intensive care unit patients. Especially patients diagnosed with ventriculitis caused by a bacterial infection have a bad outcome. Therefore, antibiotic therapy is the only causal opportunity to treat those infections. However, there are many chances in pharmacokinetic and -dynamic in critically ill patients with unpredictable antibiotic concentrations. Furthermore, it is important that the concentration in the blood as well as in the effect-compartment "CSF" is sufficient. Less data of the last years describe antibiotic concentrations in the CSF and show subtherapeutic levels, which is endangering for the therapeutic success. The introduced study is a prospective, observational study that analyses antibiotic concentrations in CSF in critically ill patients. The distribution between CSF and blood will be evaluated by comparing these two compartments.

Details
Condition Cerebral Ventriculitis
Age 18years - 100years
Clinical Study IdentifierNCT04426383
SponsorLudwig-Maximilians - University of Munich
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

written approval of the legal guardian
external ventricular drainage
antibiotic therapy

Exclusion Criteria

no approval
no antibiotic therapy or no external ventricular drainage
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