CO2 Laser Revision for Burn Related Donor Site Scars

  • STATUS
    Recruiting
  • participants needed
    25
  • sponsor
    Medstar Health Research Institute
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Updated on 5 August 2020
See if I qualify
scarring
laser therapy
compression therapy
third degree burn
occupational therapies

Summary

Scarring from burn wounds remains a chronic and often severe sequela of burn injury. Burn wounds may be left to heal by secondary intention or treated with surgical skin grafting; in both circumstances, significant scars likely result. When surgical skin grafting is employed, skin graft harvest sites ("donor sites") likewise result in clinically significant scars.

This study will have interventional and observational components. Patients will receive the standard fractional ablative CO2 treatments to their scars resulting from burn wounds allowed to heal by secondary intention and/or those treated with skin grafts. These will be prospectively observed for the duration of the study as well as adjacent normal skin. In addition, a donor site that meets inclusion criteria that would not have otherwise received LSR will be identified as a treatment site. Patients with have one half of their donor sites randomized to standard of care (SOC) treatment, which consists of wound dressings, compression therapy, physical and occupational therapies and the other half randomized to SOC + ablative fractional CO2 laser therapy (LSR).

Details
Condition Scar, Burn Scar, Skin Graft Scar
Age 18years - 100years
Treatment fractional CO2 laser
Clinical Study IdentifierNCT04456127
SponsorMedstar Health Research Institute
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

years of age
At least 1 second or third degree burn wound that required treatment with split-thickness skin grafts
Donor site with at least a 4 x 4 inch surface area
Able to return to clinical site for treatments and assessments of burn injuries

Exclusion Criteria

Pregnancy or nursing
Oral retinoid medication use within the past 6 months
Medical history of Ehlers-Danlos syndrome, AIDS
Nutritional deficiencies in the opinion of the investigator that would affect wound healing
Wounds complicated by clinically significant infection within past 30 days
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