Highly Suppressive Treg in Delayed and Slow Graft Function After Kidney Transplantation

  • STATUS
    Recruiting
  • days left to enroll
    56
  • participants needed
    140
  • sponsor
    St. Louis University
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Updated on 5 August 2020
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kidney transplant
ischemia
graft failure
ischemia-reperfusion injury
ischemic reperfusion injury

Summary

Delayed/slow graft function is the most common complication after kidney transplantation with an incidence over 20% and is the result of ischemia-reperfusion injury. The increased use of marginal kidney grafts to palliate the organ shortage is leading to a continued rise in the incidence of delayed/slow graft function. Delayed/slow graft function, however, is associated with an increased risk of acute rejection and graft failure. There are currently no clinically accepted biomarkers and no specific treatments for delayed/slow graft function. Regulatory T cells are protective in ischemia-reperfusion injury and rejection by suppressing pathologic immune responses. We hypothesize that the pre-transplant measurement of highly suppressive regulatory T cell is an accurate biomarker for delayed/slow graft function and its immunologic consequences. Ultimately, marginal kidney graft allocation could be directed to regulatory T cell-robust recipients and regulatory T cell-directed therapies could decrease marginal kidney graft discards without increasing delayed/slow graft function or impacting outcomes.

Details
Condition DGF, Kidney Transplant; Complications
Age 18years - 100years
Treatment Highly suppressive Treg measurement
Clinical Study IdentifierNCT04414111
SponsorSt. Louis University
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

Adult kidney transplant candidates immediately prior to their kidney transplant surgery

Exclusion Criteria

< 18 years old
Active immunosuppressive drug use
Hepatitis C
HIV
Clear my responses
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