Plasma Radiofrequency Ablation at Low Temperature Versus Electrocautery Block Resection at High Frequency for Localized Recurrent Nasopharyngeal Carcinoma

  • STATUS
    Recruiting
  • participants needed
    248
  • sponsor
    Sun Yat-sen University
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Updated on 5 August 2020
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cancer
radiofrequency ablation

Summary

This study aims at exploring whether plasma radiofrequency ablation at low temperature is associated with better survival outcome in localized recurrent nasopharyngeal carcinoma by conducting a randomized controlled trial of plasma radiofrequency ablation at low temperature versus electrocautery block resection at high frequency for localized recurrent nasopharyngeal carcinoma. If the hypothesis is confirmed, it is expected to provide a convenient choice for the surgical treatment of localized recurrent nasopharyngeal carcinoma.

Details
Condition Surgery, Surgical aspects, Surgery, Recurrent Nasopharyngeal Carcinoma
Age 18years - 70years
Treatment Plasma radiofrequency ablation, Electrocautery block resection
Clinical Study IdentifierNCT04425265
SponsorSun Yat-sen University
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

At least 6 months disease free interval (defined as duration between the initial course of radiotherapy and recurrence)
Histopathologically diagnosed with undifferentiated or differentiated, nonkeratinizing nasopharyngeal carcinoma
Resectable recurrent nasopharyngeal carcinoma
recurrent T1N0M0 according to the American Joint Committee on Cancer (AJCC) 8th staging B) recurrent T2N0M0(the tumor was confined to the surface of the parapharyngeal space and was more than 0.5cm away from the internal carotid artery) according to the American Joint Committee on Cancer (AJCC) 8th staging
Age: 18-70 years old
Subjects must sign an informed consent form

Exclusion Criteria

Karnofsky score (KPS)70
Has known Subjects with other malignant tumors
Has seriously mental disease
Uncontrolled clinically significant heart disease and Pulmonary dysfunction
Pregnancy or breast feeding
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