4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy

  • STATUS
    Recruiting
  • participants needed
    58
  • sponsor
    Centre Hospitalier Universitaire, Amiens
Send
Updated on 5 August 2020
See if I qualify
fibrosis
MRI
hypertrophy
cardiomyopathy
obstruction
doppler echocardiography

Summary

Hypertrophic cardiomyopathy (HCM) is a frequent cardiac pathology with an estimated prevalence of 1/500 in France. The main risk factor for sudden death in this pathology is the presence and extent of left ventricular obstruction. To date, the only method allowing a reliable assessment of the extent of left ventricular obstruction is Doppler echocardiography. All patients with HCM should undergo cardiac magnetic resonance imaging (MRI) to confirm the diagnosis and for the detection of fibrosis, but conventional sequences cannot reliably assess the obstruction. 4D-flow MRI provides a complete coverage of an entire volume with the ability to simultaneously measure the outputs of all vessels within that volume in a single sequence and might be able to quantify left ventricular obstruction.

The main objective of this study is to compare the quantification of left ventricular obstruction in hypertrophic cardiomyopathy by Doppler echocardiography and 4D flow MRI.

Details
Condition Echocardiography, Hypertrophic Cardiomyopathy, Cardiomyopathy, Cardiomyopathy, Obstruction
Age 18years - 100years
Treatment Cardiac magnetic resonance imaging (MRI)
Clinical Study IdentifierNCT04439942
SponsorCentre Hospitalier Universitaire, Amiens
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age 18 years old
Presence of a Hypertrophic cardiomyopathy (HCM)
Affiliation to a social security program
Ability of the subject to understand and express opposition

Exclusion Criteria

Major obesity (> 140 kg) not allowing the patient to enter the tunnel of the machine whose diameter is less than 70cm
Age < 18
Person under guardianship or curators
Pregnant woman
Allergy to gadolinium chelates
Claustrophobia
Any contraindications to MRI
Clear my responses
Read more

How to participate?

Step 1 Connect with a study center
Message sent successfully.
We have submitted the information you provided to the research team at the location you chose. For your records, we have sent a copy of the message to your email address.
If you would like to be informed of other studies that may be of interest to you, you may sign up for Patient Notification Service.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

First name*
Last name*
Email*
Phone number*
Other language

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Browse trials for

fibrosis
MRI
hypertrophy
cardiomyopathy
obstruction
doppler echocardiography

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.