Efficacy of Morphine Versus Dexmedetomidine as an Adjunct to Caudal Anesthesia

  • STATUS
    Recruiting
  • participants needed
    50
  • sponsor
    Cairo University
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Updated on 5 August 2020
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morphine
local anesthetic
dexmedetomidine
bupivacaine
analgesia
pain relieving
local anesthesia
pediatric
patent ductus arteriosus ligation

Summary

The aim of this study is to compare the duration of post-operative analgesia, sedation, and any side effects of caudal dexmedetomidine versus morphine in combination with bupivacaine in pediatric patients undergoing thoracic surgeries.

Description

The patients will be randomized in a blinded fashion to get enrolled into 2 equal groups: Group A patients (n =25) will receive caudal epidural analgesia using dexmedetomidine with bupivacaine, whereas Group B patients (n = 25) will receive caudal epidural analgesia using morphine with bupivacaine.

Randomization will be achieved by using an online random number generator. Patient codes will be placed into sequentially numbered sealed opaque envelopes by a research assistant who is not involved in the study. An anesthesia resident not involved in patient management will be responsible for opening the envelope. The anesthesia resident will prepare the study drug according to the instructions contained within each envelope and give it to the anesthesiologist.

Details
Condition Local anesthesia
Age 1years - 6years
Treatment Morphine, dexmedetomidine
Clinical Study IdentifierNCT04445636
SponsorCairo University
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

ASA I, II, III
Patients undergoing lung cyst excision
Patients undergoing Patent Ductus Arteriosus ligation

Exclusion Criteria

Preoperative mechanical ventilation
Preoperative inotropic support
History of mental retardation or delayed development that may interfere with pain intensity assessment
Known or suspected coagulopathy
Any congenital anomalies of the sacrum or any infection at the site of injection
Known or suspected allergy to any of the studied drugs
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morphine
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