Furosemide Stress Test for the Prediction of Acute Kidney Injury Severity in Acute Heart Failure Patients

  • STATUS
    Recruiting
  • participants needed
    257
  • sponsor
    Chiang Mai University
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Updated on 5 August 2020
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acute renal failure
heart failure
diuretics
acute heart failure
exercise stress test
furosemide
edema
chest x-ray
renal injury
central venous pressure

Summary

This study is aim to study the changes of serum creatinine levels at 72 hours after admission in patients with acute heart failure who has diuretic resistance compared to those who do not have diuretic resistance from furosemide stress test

Description

This study is an observational prospective study to demonstrate a prognosis of acute heart failure patients who have diuretic resistance compared to those who do not have diuretic resistance from furosemide stress test. The primary outcome is changes of serum creatinine levels at 72 hours compared to baseline values at the time of admission.

Details
Condition Renal Failure, Renal Failure, Acute renal failure, Heart failure, Heart failure, Heart disease, Heart disease
Age 18years - 100years
Treatment Furosemide stress test
Clinical Study IdentifierNCT04464811
SponsorChiang Mai University
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

Age 18 years
Diagnosis of acute heart failure which is defined by 2 of the 3 following features: 2+ leg edema, jugular venous pressure >10 cm from physical examination or central venous pressure >10 mmHg, and bilateral pulmonary edema or bilateral pleural effusion from chest radiography
Patients consent to participate into the study

Exclusion Criteria

Patients who receive furosemide 500 mg/day or hydrochlorothiazide 100 mg/day or spironolactone 100 mg/day or tolvaptan of any doses
Patients who have systolic blood pressure <100 mmHg or who need vasoactive drugs inotropic agents (except dobutamine)
Patients with intravascular volume depletion from clinical evaluation
Patients with chronic kidney disease stage 5 (estimated glomerular filtration rate <15 ml/min/1.73 m2) or patients who receive maintenance dialysis
Patients who require renal replacement therapy at the time of admission
Patients whom diagnosed hypertrophic obstructive cardiomyopathy, severe valvular stenosis or complex congenital heart disease
Patients with sepsis or systemic infection
Pregnant women
Patients who have history of furosemide, spironolactone or hydrochlorothiazide allergy
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acute renal failure
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renal injury
central venous pressure

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