Immunoglobulin G Antibody Immune Response Profile Following Infection With SARS-CoV-2 in COVID-19 Egyptian Patients

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    Sohag University
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Updated on 5 August 2020
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immunoglobulins
SARS
coronavirus infection
acute respiratory syndrome (sars)

Summary

The objective of this study is to detect the evidence on the immune response following acute SARS-CoV-2 infections. the study will report the profile of IgG specific antibodies levels to SARS-CoV-2 infection found in recovered coronavirus disease (COVID-19) patients after infection for both symptomatic and asymptomatic patients.

Description

A total of 30 COVID-19 patients for the study will be enrolled. All the patients enrolled were confirmed to be infected with SARS-CoV-2 by RT-PCR assay for nasal and pharyngeal swab specimens.

For the study, serum samples of the 30 patients will be collected and will be investigated for the detection rate for immunoglobulin G (IgG). The first sample will be collected 2 weeks after the second negative RT-PCR assay for nasal and pharyngeal swab specimens and 6 samples will be collected after that for 6 months later; one serum sample tested every month for 6 months after.

The following questions will be addressed:-

  1. What proportion of confirmed cases develops specific IgG antibodies to SARS-CoV-2?
  2. How long is the duration of detection of serum IgG antibodies and antibody titres over time following infection with SARS-CoV-2?

Details
Condition COVID19
Age 16years - 90years
Clinical Study IdentifierNCT04483622
SponsorSohag University
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

patients with recent COVID- 19 infection(2 weeks after the second negative RT-PCR assay)

Exclusion Criteria

patients on immune-suppressive therapy
patients with immunological disease
Clear my responses
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