Imaging SARS-CoV-2 Involvement of Leptomeninges Olfactory and Limbic Areas

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
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Updated on 5 August 2020
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Summary

When patients arrive in the waiting room of the MRI department, patients will be given the briefing note explaining the purpose of the study and how it is going. During the consultation, the radiologist will check the inclusion and non-inclusion criteria, and will take the time to answer all of the patient's questions about the study (or his family member by telephone if the patient does not is not in a condition to give its consent).

The MRI examination will be performed on a 3T multi-parametric MRI. If the neurological disorder presented by the patient does not require an injection as part of routine care, only a high resolution 3D T2 sequence on the nasosinus cavities and the olfactory tract, called bFFE-Xd for approximately 2 min.

If the neurological disorder presented by the patient requires an injection as part of current care, the examination will be completed with the nasosinus and olfactory 3D bFFE-Xd sequence, and the following additional sequences performed after post injection: a

  • 3D FABIR 0.9 sequence covering the brain, dedicated to exploring the subarachnoid spaces;
  • a 3D T1 TSE 0.7 sequence covering the brain looking for meningeal or encephalic contrast enhancement,
  • FLAIR HR coronal sequence (high resolution) exploring the limbic system.
  • Optional: a 3D FLAIR "labyrinth" sequence in the event of hearing / balance problems; a DCE infusion sequence (T1-WI) on the olfactory tract if olfactory disorder, which will be the first sequence made at the time of injection.

Details
Condition Estimate, With the Contribution of Optimized MRI, the Prevalence of Neurological and Neurovascular Manifestations on Imaging in the Event of SARS-CoV-2
Age 18years - 100years
Treatment MRI
Clinical Study IdentifierNCT04448054
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on5 August 2020

Eligibility

 Yes No Not Sure

Inclusion Criteria

Patient> 18 years old Express consent to participate in the study Affiliate or
beneficiary of a social security scheme Patient with suspected SARS-CoV-2
infection in an epidemic context, confirmed or not by PCR, or close contact
with a case confirmed by PCR, typical chest scanner (non-systematized frosted
glass areas predominantly sub-pleural, and at a later stage of alveolar
condensation without excavations, nodules or masses) or positive serology
Patient to benefit from a brain MRI for an indication within the scope of care

Exclusion Criteria

Patient benefiting from a legal protection measure Pregnant or breastfeeding
woman
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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